rs10188292 - IL1F10 - RNU6-1180P

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic evidence for serum amyloid P component as a drug target in neurodegenerative disorders - Unknown journal (n.d.) · Unknown authors · PubMed 39013416

  ABSTRACT: The mechanisms responsible for neuronal death causing cognitive loss in Alzheimer's disease (AD) and many other dementias are not known. Serum amyloid P component (SAP) is a constitutive plasma protein, which is cytotoxic for cerebral neurones and also promotes formation and persistence of cerebral Aβ amyloid and neurofibrillary tangles. Circulating SAP, which is produced exclusively by the liver, is normally almost completely excluded from the brain. Conditions increasing brain exposure to SAP increase dementia risk, consistent with a causative role in neurodegeneration. Furthermore, neocortex content of SAP is strongly and independently associated with dementia at death. Here, seeking genomic evidence for a causal link of SAP with neurodegeneration, we meta-analysed three geno

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