rs10188036 - STRADB, TRAK2

Magnitude 4.5 · 1 study on file

Reported associations

• A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene-environment interaction. - Journal of psychiatry & neuroscience : JPN (2021) · Sun J, Kranzler HR, Gelernter J, Bi J · PubMed 31490055

  Phenotypic heterogeneity and complicated gene-environment interplay in etiology are among the primary factors that hinder the identification of genetic variants associated with cocaine use disorder. To detect novel genetic variants associated with cocaine use disorder, we derived disease traits with reduced phenotypic heterogeneity using cluster analysis of a study sample (n = 9965). We then used these traits in genome-wide association tests, performed separately for 2070 African Americans and 1570 European Americans, using a new mixed model that accounted for the moderating effects of 5 childhood environmental factors. We used an independent sample (918 African Americans, 1382 European Americans) for replication. The cluster analysis yielded 5 cocaine use disorder subtypes, of which sub

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