Expressive

rs10186133 - IL1F10 - RNU6-1180P

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease - Unknown journal (n.d.) · Unknown authors · PubMed 29212778

    ABSTRACT: Supplemental Digital Content is available in the text. Rationale: Coronary artery disease (CAD) is a complex phenotype driven by genetic and environmental factors. Ninety-seven genetic risk loci have been identified to date, but the identification of additional susceptibility loci might be important to enhance our understanding of the genetic architecture of CAD. Objective: To expand the number of genome-wide significant loci, catalog functional insights, and enhance our understanding of the genetic architecture of CAD. Methods and Results: We performed a genome-wide association study in 34 541 CAD cases and 261 984 controls of UK Biobank resource followed by replication in 88 192 cases and 162 544 controls from CARDIoGRAMplusC4D. We identified 75 loci that replicated and

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • heart-healthy diet pattern Moderate

    Mediterranean and DASH diets reduce coronary artery disease risk and are evidence-based for genetic predisposition

    Emphasize vegetables, whole grains, legumes, fish, nuts, olive oil; reduce saturated fat and processed foods

Discuss with your doctor

  • cardiovascular risk assessment and screening strategy Moderate

    Genetic risk should inform personalized prevention approach and screening timing

Exercise

  • regular aerobic exercise Moderate

    Aerobic activity is the most effective lifestyle intervention for reducing coronary artery disease risk

    Aim for 150 minutes moderate-intensity aerobic activity per week

Screening

  • blood pressure and lipid levels Moderate

    T allele carriers have increased coronary artery disease risk; monitoring modifiable risk factors is essential

    Annual lipid panel and blood pressure measurement; more frequent if abnormalities detected