rs10184376 - ACVR1C
Magnitude 2.2 · 1 study on file
Reported associations
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Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484
ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to elevated lipid levels Moderate
ACVR1C rs10184376 T-allele affects lipid metabolism via altered liver gene expression (p=9.46e-7)
Screening
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lipid panel for ApoB, total cholesterol, LDL cholesterol Moderate
rs10184376 T-allele shows genome-wide significant associations with higher apolipoprotein B (p=4e-11), total cholesterol (p=1e-10), and LDL cholesterol (p=2e-10)
Baseline lipid panel if not recent; repeat per standard cardiovascular risk assessment guidelines