rs10183486 - TLK1

Magnitude 2.2 · 1 study on file

Reported associations

• Meta-analyses identify 13 novel loci associated with age at menopause and highlights DNA repair and immune pathways - Unknown journal (n.d.) · Unknown authors · PubMed 22267201

  ABSTRACT: To identify novel loci for age at natural menopause, we performed a meta-analysis of 22 genome-wide association studies in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 new age at natural menopause loci (P < 5 × 10−8). The new loci included genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG, PRIM1) and immune function (IL11, NLRP11, BAT2). Gene-set enrichment pathway analyses using the full GWAS dataset identified exodeoxyribonuclease, NFκB signalling and mitochondrial dysfunction as biological processes related to timing of menopause. FULL TEXT: [INTRO] Introduction [INTRO] Menopause is the cessation of reproductive function of the human ovaries. This life stage is assoc

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