Expressive

rs10183417 - CDC42EP3-AS1, PIRAT1

Magnitude 2.2 · 1 study on file

Reported associations

  • Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation - Unknown journal (n.d.) · Unknown authors · PubMed 40645996

    ABSTRACT: Atrial fibrillation (AF) is a common cardiac arrhythmia with strong genetic components, yet its underlying molecular mechanisms and potential therapeutic targets remain incompletely understood. We conducted a cross-population genome-wide meta-analysis of 252,438 AF cases and identified 525 loci that met genome-wide significance. Two loci of PITX2 and ZFHX3 genes were identified as shared across populations of different ancestries. Comprehensive gene prioritization approaches reinforced the role of muscle development and heart contraction while also uncovering additional pathways, including cellular response to transforming growth factor-beta. Population-specific genetic correlations uncovered common and unique circulatory comorbidities between Europeans and Africans. Mendelian ra

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Mediterranean or DASH diet pattern Moderate

    Heart-healthy dietary patterns reduce cardiovascular disease and AF incidence in at-risk populations

    Emphasize vegetables, whole grains, fish, nuts, and olive oil; limit processed foods

Discuss with your doctor

  • Preventive cardiology evaluation for genetic AF risk Moderate

    Genetic variant associated with significantly increased AF risk may warrant preventive evaluation and personalized risk reduction strategy

    Consider cardiology consultation to discuss baseline evaluation and prevention options

Exercise

  • Regular moderate aerobic exercise Moderate

    Physical activity reduces cardiovascular disease and arrhythmia risk in genetically predisposed individuals

    150 minutes per week of moderate aerobic activity

Lifestyle

  • Limit alcohol consumption Moderate

    Excessive alcohol is a known AF trigger; genetic predisposition may amplify this risk

    Limit to 1-2 standard drinks per day or eliminate if arrhythmia-prone

Screening

  • Baseline atrial fibrillation screening Moderate

    Genetic variant rs10183417 is significantly associated with increased atrial fibrillation risk (GWAS p=2e-16, n=2.5M)

    Obtain baseline ECG and discuss monitoring strategy with physician