rs10181075 - CHORDC1P1 - LINC01819
Magnitude 2.2 · 1 study on file
Reported associations
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High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 35762941
ABSTRACT: Purpose To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. Methods Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics. Results Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per 10-mm Hg inc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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low sodium diet Moderate
Sodium intake directly influences systolic blood pressure; those with genetic predisposition should manage dietary sodium carefully.
Target less than 2300mg sodium daily, or under 1500mg if hypertensive
- GWAS_CATALOG:35762941
Exercise
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aerobic exercise Moderate
Aerobic exercise reduces systolic blood pressure; this SNP increases baseline BP risk, making consistent activity especially important.
150 minutes per week of moderate-intensity aerobic exercise
- GWAS_CATALOG:35762941
Screening
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blood pressure screening Moderate
Genetic predisposition to elevated systolic blood pressure requires regular monitoring to detect hypertension early.
Annual blood pressure screening, or every 6 months if hypertensive
- GWAS_CATALOG:35762941