rs10180334 - LINC01122
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-Wide Interaction Study of Dietary Intake and Colorectal Cancer Risk in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 38411962
ABSTRACT: Key Points Question Which variants and genes modify the association of dietary intake with colorectal cancer (CRC) risk, and what are the underlying pathways for diet-CRC associations? Findings In this nested case-control study including 4686 patients with incident CRC and 14 058 matched controls, 324 variants suggestively interacted with 11 dietary factors, and multiple variants of EPDR1 were found to interact with fish intake on CRC risk. Several pathways were detected for the association between milk, cheese, tea, and alcohol consumption and CRC risk. Meaning The findings of this study support evidence for possible pathways involved in the association between diet and CRC. Importance Candidate gene analysis approaches have shown that colorectal cancer (CRC) risk attributable
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Limit red meat intake, particularly processed varieties Moderate
Risk allele A shows significant gene-environment interaction with red meat intake in colorectal cancer development
Consider limiting red meat to 1-2 servings per week