rs10179687 - LINC01117
Magnitude 2.2 · 1 study on file
Reported associations
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A Genomics England haplotype reference panel and imputation of UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 39134668
ABSTRACT: We built a reference panel with 342 million autosomal variants using 78,195 individuals from the Genomics England (GEL) dataset, achieving a phasing switch error rate of 0.18% for European samples and imputation quality of r2 = 0.75 for variants with minor allele frequencies as low as 2 × 10−4 in white British samples. The GEL-imputed UK Biobank genome-wide association analysis identified 70% of associations found by direct exome sequencing (P < 2.18 × 10−11), while extending testing of rare variants to the entire genome. Coding variants dominated the rare-variant genome-wide association results, implying less disruptive effects of rare non-coding variants. A Genomics England haplotype reference panel constructed using sequence data from 78,195 individuals
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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blood pressure management strategies Moderate
Genetic variants affecting systolic blood pressure may warrant personalized management based on individual cardiovascular risk profile.
discuss with healthcare provider whether additional blood pressure management is warranted
Screening
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blood pressure monitoring Moderate
rs10179687 is associated with systolic blood pressure variation in a large-scale GWAS, suggesting genetic contribution to blood pressure regulation.
monitor blood pressure at least annually