rs10179686 - TMEM163

Magnitude 4.5 · 1 study on file

Reported associations

• Shared genetic susceptibility to ischemic stroke and coronary artery disease - a genome-wide analysis of common variants - Unknown journal (n.d.) · Unknown authors · PubMed 24262325

  ABSTRACT: Summary Background and Purpose Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each have a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases. Methods Genome-wide association data were obtained from the METASTROKE, CARDIoGRAM, and C4D consortia. We first analyzed common variants reaching a nominal threshold of significance (p<0.01) for CAD for their association with IS and vice versa. We then examined specific overlap across phenotypes for variants that reached a high threshold of significance. Finally, we conducted a joint meta-analysis on the combined phenotype of IS or CAD. Corresponding analyses were performed restricted to the 2,167 individuals with the

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