rs10176968 - SLC8A1-AS1
Magnitude 2.8 · 1 study on file
Reported associations
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Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians - Unknown journal (n.d.) · Unknown authors · PubMed 32131869
ABSTRACT: Background Hallux valgus, one of the most common structural foot deformities, is highly heritable. However, previous efforts to elucidate the genetic underpinnings of hallux valgus through a genome-wide association study (GWAS) conducted in 4409 Caucasians did not identify genome-wide significant associations with hallux valgus in both gender-specific and sex-combined GWAS meta-analyses. In this analysis, we add newly available data and more densely imputed genotypes to identify novel genetic variants associated with hallux valgus. Methods A total of 5925 individuals of European Ancestry were categorized into two groups: 'hallux valgus present' (n = 2314) or 'no deformity' (n = 3611) as determined by trained examiners or using the Manchester grading scale. Genotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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supportive footwear with wide toe box and arch support Moderate
Appropriate footwear prevents hallux valgus progression; rs10176968 A allele carriers have elevated deformity risk.
Select shoes with wide forefoot, firm arch support, heel less than 2 inches; avoid tight toe boxes.
Screening
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baseline podiatric assessment for hallux valgus monitoring Moderate
rs10176968 A allele significantly associates with hallux valgus; early assessment enables progression monitoring.
Baseline podiatric evaluation; annual follow-up if valgus deformity signs noted.