rs10175809 - UGT1A10, UGT1A8, UGT1A9, UGT1A7

Magnitude 2.0 · 1 study on file

Reported associations

• Insomnia affects the levels of plasma bilirubin and protein metabolism: an observational study and GWGEIS in UK Biobank cohort. - Sleep medicine (2021) · Chu X, Liu L, Ye J, Wen Y, Li P, Cheng B, Cheng S, Zhang L, Qi X, Ma M, Liang C, Kafle OP, Wu C, Wang S, Wang X, Ning Y, Zhang F · PubMed 34343768

  We aim to explore the mechanism of relationship between insomnia and liver metabolism by examining the gene × insomnia interactions. Individual level genotypic and phenotypic data were obtained from the UK Biobank cohort. Regression analysis was first conducted to test the association of insomnia with plasma total bilirubin (TBil; n = 186,793), direct bilirubin (DBil; n = 159,854) and total protein (TP; n = 171,574) in UK Biobank cohort. Second, genome-wide gene-environment interaction study (GWGEIS) was conducted by PLINK 2.0, and FUMA platform was used to identify enriched pathway terms. In UK Biobank cohort, we found that TP (P < 2.00 × 10 ), DBil (P = 1.72 × 10 ) and TBil (P = 3.38 × 10 ) were significantly associated with insomnia. GWGEIS of both DBil and TBil

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