rs10173066 - LINC00486

Magnitude 2.2 · 1 study on file

Reported associations

• Mapping and annotating genomic loci to prioritize genes and implicate distinct polygenic adaptations for skin color - Unknown journal (n.d.) · Unknown authors · PubMed 38849341

  ABSTRACT: Evidence for adaptation of human skin color to regional ultraviolet radiation suggests shared and distinct genetic variants across populations. However, skin color evolution and genetics in East Asians are understudied. We quantified skin color in 48,433 East Asians using image analysis and identified associated genetic variants and potential causal genes for skin color as well as their polygenic interplay with sun exposure. This genome-wide association study (GWAS) identified 12 known and 11 previously unreported loci and SNP-based heritability was 23-24%. Potential causal genes were determined through the identification of nonsynonymous variants, colocalization with gene expression in skin tissues, and expression levels in melanocytes. Genomic loci associated with pigmentatio

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