rs10170665 - CYP2C56P - GRB14

Magnitude 2.0 · 1 study on file

Reported associations

• Genomic variants at 20p11 were associated with body fat mass in the European population - Obesity (Silver Spring, Md.) (2017) · Pei YF, Ren HG, Liu L, Li X, Fang C, Huang Y, Hu WZ, Kong WW, Feng AP, You XY, Zhao W, Shen H, Tian Q, Zhang YH, Deng HW, Zhang L · PubMed 28224759

  ABSTRACT: Objective Body fat mass (BFM) is more homogeneous and accurate than body total mass in measuring obesity, but has rarely been studied. Aiming to uncover the genetic basis of fat-induced obesity, we performed a genome-wide association meta-analysis of BFM, after adjustment by body lean mass, in the European population. Methods Three samples of European ancestry were included into the meta-analysis: the Framingham heart study (FHS, N=6,004), the Kansas-city osteoporosis study (KCOS, N=2,207) and the Omaha osteoporosis study (OOS, N=968). Results At genome-wide significance level (α=5.0×10−8), we identified a cluster of 10 SNPs at chromosomal region 20p11 that were associated with BFM (lead SNP rs2069126 p=1.82×10−9, closest gene SLC24A3) in 9,179 subjects. One of the top SNP

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