rs10170310 - SPOPL

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study of patient and clinician rated global impression severity during antipsychotic treatment - Pharmacogenetics and genomics (2013) · Clark SL, Souza RP, Adkins DE, Aberg K, Bukszár J, McClay JL, Sullivan PF, van den Oord EJ · PubMed 23241943

  ABSTRACT: Objective Examine the unique and congruent findings between multiple raters in a genome-wide association studies (GWAS) in the context of understanding individual differences in treatment response during antipsychotic therapy for schizophrenia. Methods We performed GWAS to search for genetic variation affecting treatment response. The analysis sample consisted of 738 patients with schizophrenia, successfully genotyped for ~492K SNPs from the Clinical Antipsychotic Trial of Intervention Effectiveness (CATIE). Outcomes included both clinician and patient report of illness severity on global impression scales, the CGI-S and PGI, respectively. Our criterion for genome-wide significance was a pre-specified threshold ensuring that, on average, only 10% of the significant findings are f

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