rs10169524 - CKAP2L - IL1A

Magnitude 2.2 · 1 study on file

Reported associations

• The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases - Unknown journal (n.d.) · Unknown authors · PubMed 39794498

  ABSTRACT: Circulating cytokines orchestrate immune reactions and are promising drug targets for immune-mediated and inflammatory diseases. Exploring the genetic architecture of circulating cytokine levels could yield key insights into causal mediators of human disease. Here, we performed genome-wide association studies (GWAS) for 40 circulating cytokines in meta-analyses of 74,783 individuals. We detected 359 significant associations between cytokine levels and variants in 169 independent loci, including 150 trans- and 19 cis-acting loci. Integration with transcriptomic data point to key regulatory mechanisms, such as the buffering function of the Atypical Chemokine Receptor 1 (ACKR1) acting as scavenger for multiple chemokines and the role of tumor necrosis factor receptor-associated fact

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