Expressive

rs1016871223 - IGKV2-23 - IGKV2-24

Magnitude 2.2 · 1 study on file

Reported associations

  • Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases - Unknown journal (n.d.) · Unknown authors · PubMed 41644669

    ABSTRACT: Thyroid diseases are common and highly heritable. We performed a meta-analysis of genome-wide association studies from 19 biobanks for five thyroid diseases: thyroid cancer (ThC), benign nodular goiter, Graves' disease, lymphocytic thyroiditis and primary hypothyroidism. We analyzed genetic association data from ~2.9 million genomes and identified 313 known and 570 new independent loci linked to thyroid diseases. We discovered genetic correlations between ThC, benign nodular goiter and autoimmune thyroid diseases (rg = 0.16-0.97). Telomere maintenance genes contributed to benign and malignant thyroid nodular disease risk, whereas cell cycle, DNA repair and damage response genes were associated with ThC. We propose a paradigm that explains genetic predisposition to benign

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • preventive thyroid monitoring plan Moderate

    Increased genetic risk for hypothyroidism warrants healthcare planning for appropriate screening intervals and early intervention

    • GWAS_CATALOG:41644669

Screening

  • TPO antibodies Moderate

    Variant in immunoglobulin region indicates potential autoimmune thyroid component; TPO antibodies confirm Hashimoto's etiology if present

    Anti-TPO antibody testing once if risk status known

    • GWAS_CATALOG:41644669
  • thyroid function screening Moderate

    Genetic variant associated with increased hypothyroidism risk; periodic TSH monitoring enables early detection and treatment initiation

    TSH testing annually or per healthcare provider recommendation

    • GWAS_CATALOG:41644669