Expressive

rs10167307 - EVA1A

Magnitude 2.8 · 1 study on file

Reported associations

  • Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients - Unknown journal (n.d.) · Unknown authors · PubMed 32238385

    ABSTRACT: Objectives Genome-wide meta-analyses of clinically defined gout were performed to identify subtype-specific susceptibility loci. Evaluation using selection pressure analysis with these loci was also conducted to investigate genetic risks characteristic of the Japanese population over the last 2000-3000 years. Methods Two genome-wide association studies (GWASs) of 3053 clinically defined gout cases and 4554 controls from Japanese males were performed using the Japonica Array and Illumina Array platforms. About 7.2 million single-nucleotide polymorphisms were meta-analysed after imputation. Patients were then divided into four clinical subtypes (the renal underexcretion type, renal overload type, combined type and normal type), and meta-analyses were conducted in the same manner.

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • excessive alcohol, especially beer Moderate

    Alcohol increases uric acid production and decreases renal excretion

    limit to <=1 drink/day (women) or <=2 drinks/day (men)

  • high-purine foods Moderate

    Dietary purines increase serum uric acid, the substrate for gout crystal formation

    limit red meat, organ meats, and high-fructose foods to <2 servings/week

  • water intake for hydration Moderate

    Increased urine volume reduces urinary uric acid concentration and crystal precipitation

    drink >=2.5 liters water daily

Lifestyle

  • weight management for gout prevention Moderate

    Obesity is associated with elevated serum uric acid and gout risk independent of diet

    maintain BMI <25 kg/m2

Screening

  • gout risk assessment with healthcare provider Moderate

    GWAS association indicates elevated genetic risk for gout; baseline assessment enables targeted prevention

    baseline serum uric acid measurement and periodic screening