rs10165883 - GMCL1 - SNRNP27
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-Ethnic Genome-wide Association Study for Atrial Fibrillation - Unknown journal (n.d.) · Unknown authors · PubMed 29892015
ABSTRACT: Atrial fibrillation (AF) affects over 33 million individuals worldwide and has a complex heritability. We conducted the largest meta-analysis of genome-wide association studies for AF to date, consisting of over half a million individuals including 65,446 with AF. In total, we identified 97 loci significantly associated with AF including 67 of which were novel in a combined-ancestry analysis, and 3 in a European specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait loci (eQTL) analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Atrial fibrillation risk assessment and prevention strategy Moderate
rs10165883 C allele associated with increased AF risk; individualized stratification and tailored prevention approach needed
Screening
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Atrial fibrillation screening with electrocardiogram Moderate
rs10165883 C allele increases atrial fibrillation risk (OR=1.070, p=6.00e-19)
Obtain baseline ECG; discuss ongoing monitoring schedule with cardiologist