rs1016565 - H3P29 - LINC-ADAIN
Magnitude 2.2 · 1 study on file
Reported associations
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Identification of type 2 diabetes loci in 433,540 East Asian individuals - Unknown journal (n.d.) · Unknown authors · PubMed 32499647
ABSTRACT: SUMMARY Meta-analyses of genome-wide association studies (GWAS) have identified >240 loci associated with type 2 diabetes (T2D), however most loci have been identified in analyses of European-ancestry individuals. To examine T2D risk in East Asian individuals, we meta-analyzed GWAS data in 77,418 cases and 356,122 controls. In the main analysis, we identified 301 distinct association signals at 183 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 61 loci newly implicated in T2D predisposition. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. New associations include signals in/near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic risk factor for Type 2 diabetes Moderate
rs1016565 A allele is associated with Type 2 diabetes in genome-wide association study.
Discuss this genetic risk and appropriate screening interval with healthcare provider
Screening
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Type 2 diabetes screening Moderate
Carrier of rs1016565 risk allele (A) is associated with increased Type 2 diabetes risk in large cohort study.
Fasting glucose or HbA1c screening every 1-2 years or as clinically indicated