Expressive

rs10162671 - OAZ2 - RBPMS2; SPG21

Magnitude 4.5 · 2 studies on file

Reported associations

  • Colorectal cancer risk susceptibility loci in a Swedish population. - Molecular carcinogenesis (2022) · Liu W, Mahdessian H, Helgadottir H, Zhou X, Thutkawkorapin J, Jiao X, Wolk A, Lindblom A · PubMed 34758156

    To search for colorectal cancer (CRC) risk loci, Swedish samples were used for a genome-wide haplotype analysis. A logistic regression model was employed in 2663 CRC cases and 1642 controls in the discovery analysis. Three analyses were done, on all, familial-, and nonfamilial CRC samples and only results with odds ratio (OR) > 1 were analyzed. single nucleotide polymorphism (SNP) analysis did not generate any statistically significant results. Haplotype analysis suggested novel loci, on chromosome 2q36.1 (OR = 1.71, p value = 5.6924 × 10 ) in all CRC samples, chromosome 1q43 (OR = 4.04 p value = 3.24 × 10 ) in familial CRC samples, and two hits in nonfamilial CRC samples, chromosomes 2q36.1 (OR = 1.71 p value = 5.69 × 10 ) and 3p24.3 (OR = 

  • Genome-wide discovery for diabetes-dependent triglycerides-associated loci - Unknown journal (n.d.) · Unknown authors · PubMed 36269708

    ABSTRACT: Purpose We aimed to discover loci associated with triglyceride (TG) levels in the context of type 2 diabetes (T2D). We conducted a genome-wide association study (GWAS) in 424,120 genotyped participants of the UK Biobank (UKB) with T2D status and TG levels. Methods We stratified the cohort based on T2D status and conducted association analyses of TG levels for genetic variants with minor allele count (MAC) at least 20 in each stratum. Effect differences of genetic variants by T2D status were determined by Cochran's Q-test and we validated the significantly associated variants in the Mass General Brigham Biobank (MGBB). Results Among 21,176 T2D and 402,944 non-T2D samples from UKB, stratified GWAS identified 19 and 315 genomic risk loci significantly associated with TG levels, re

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