rs10161304 - KSR2
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency - Unknown journal (n.d.) · Unknown authors · PubMed 36267918
ABSTRACT: Summary Premature atrial contractions (PACs) are frequently observed on electrocardiograms and are associated with increased risks of atrial fibrillation (AF), stroke, and mortality. In this study, we aimed to identify genetic susceptibility loci for PAC frequency. We performed a genome-wide association study meta-analysis with PAC frequency obtained from ambulatory cardiac monitoring in 4,831 individuals of European ancestry. We identified a genome-wide significant locus at the SCN5A gene. The lead variant, rs7373862, located in an intron of SCN5A, was associated with an increase of 0.12 [95% CI 0.08-0.16] standard deviations of the normalized PAC frequency per risk allele. Among genetic variants previously associated with AF, there was a significant enrichment in concordance
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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rs10161304 A allele and premature atrial contraction risk Moderate
GWAS study of 4831 subjects identified significant association between A allele and PAC frequency
Screening
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premature atrial contraction screening Moderate
rs10161304 A allele associated with increased premature atrial contraction frequency via reduced NOS1 expression affecting cardiac regulation
baseline 12-lead ECG and consider 24-48 hour Holter monitor