rs10160512 - LINC02755
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-Wide Interaction Study of Dietary Intake and Colorectal Cancer Risk in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 38411962
ABSTRACT: Key Points Question Which variants and genes modify the association of dietary intake with colorectal cancer (CRC) risk, and what are the underlying pathways for diet-CRC associations? Findings In this nested case-control study including 4686 patients with incident CRC and 14 058 matched controls, 324 variants suggestively interacted with 11 dietary factors, and multiple variants of EPDR1 were found to interact with fish intake on CRC risk. Several pathways were detected for the association between milk, cheese, tea, and alcohol consumption and CRC risk. Meaning The findings of this study support evidence for possible pathways involved in the association between diet and CRC. Importance Candidate gene analysis approaches have shown that colorectal cancer (CRC) risk attributable
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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limit alcohol consumption Moderate
The A allele amplifies alcohol's effect on colorectal cancer risk
Limit alcohol to moderate levels or as recommended by healthcare provider
Discuss with your doctor
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alcohol intake and colorectal cancer risk Moderate
The A allele at rs10160512 increases the effect of alcohol on colorectal cancer risk
Discuss current and target alcohol consumption with a healthcare provider
Screening
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colorectal cancer screening Moderate
The rs10160512 A allele modifies colorectal cancer risk, particularly with alcohol
Discuss screening timing and frequency with healthcare provider