rs10156113 - CACNA2D1

Magnitude 2.0 · 1 study on file

Reported associations

• Platelet response to aspirin in UK and Irish pregnancy cohorts: a genome-wide approach. - Platelets (2022) · Mone F, Gupta JK, Phelan MM, Meher S, Lian LY, Francis B, Zhang E, Mulcahy C, Alfirevic A, Mcauliffe FM, Navaratnam K · PubMed 34904537

  A multi-center prospective cross-sectional and genome-wide association study (GWAS) recruited pregnant women taking low dose aspirin. Objectives were to (i) develop pregnancy-specific 95% reference intervals for a range of laboratory based platelet function tests (PFTs); (ii) select an optimal and acceptable PFT that reflected aspirin's COX-1 inhibition in women with confirmed aspirin adherence in pregnancy; and (iii) identify genomic variants that may influence pregnant women's platelet response to aspirin.The study included two independent cohorts of pregnant women. A range of PFTs and matched phenotyping with urinary 11-dehydrothromboxane B (11DTXB2) and nuclear magnetic resonance (NMR) spectroscopy detection of urinary salicyluric acid as a measure of aspirin adherence were performed.

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.