rs1015291 - RNU1-146P - TCP1P3
Magnitude 2.2 · 1 study on file
Reported associations
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Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney - Unknown journal (n.d.) · Unknown authors · PubMed 28739976
ABSTRACT: Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previousl
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic risk for elevated diastolic blood pressure Moderate
SNP-based genetic association may inform personalized cardiovascular prevention and screening strategy
Screening
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blood pressure screening and regular monitoring Moderate
G allele at rs1015291 associated with higher diastolic blood pressure in large population study
baseline measurement and annual screening, or more frequent if clinically indicated