rs10152300 - ADAMTSL3
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations - Unknown journal (n.d.) · Unknown authors · PubMed 30804561
ABSTRACT: Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide novel insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci with P-value < 5 × 10−8; 47 were previously described in association with either COPD or population-based lung function. Of the remaining 35 novel loci, 13 were associated with lung function in 79,055 individuals from the SpiroMeta consortium. Using gene expression and regulation data, we identified enrichment for loci in lung tissue, smooth muscle and several lung cell types. We found 14 COPD loci shared with either
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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regular aerobic exercise Moderate
Aerobic activity strengthens respiratory capacity and may help mitigate genetic COPD susceptibility.
150 minutes moderate-intensity aerobic activity per week
Lifestyle
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tobacco smoke and occupational lung irritants Moderate
ADAMTSL3 variant increases genetic susceptibility to COPD; environmental exposures compound risk.
Screening
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respiratory screening for COPD Moderate
Variant in ADAMTSL3 increases COPD risk; early detection enables treatment before disease progression.
Annual spirometry assessment starting at age 30-40