rs10150951 - IGHV3-60 - RNA5SP389
Magnitude 4.5 · 1 study on file
Reported associations
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A genome-wide association study for allergen component sensitizations identifies allergen component-specific and allergen protein group-specific associations - Unknown journal (n.d.) · Unknown authors · PubMed 37780799
ABSTRACT: Background Allergic diseases are some of the most common diseases worldwide. Genome-wide association studies (GWASs) have been conducted to elucidate the genetic factors of allergic diseases. However, no GWASs for allergen component sensitization have been performed. Objective We sought to detect genetic variants associated with differences in immune responsiveness against allergen components. Methods The participants of the present study were recruited from the Tokyo Children's Health, Illness, and Development study, and allergen component-specific IgE level at age 9 years was measured by means of allergen microarray immunoassays. We performed GWASs for allergen component sensitization against each allergen (single allergen component sensitization, number of allergen compone
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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high ragweed pollen exposure during pollination season Moderate
Genetic predisposition to increased IgE sensitization to ragweed pollen components may increase allergic response risk
Limit outdoor exposure during ragweed season (late August-October); use air filtration and keep windows closed
Screening
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ragweed pollen allergen component testing Moderate
IGHV3-60 variant increases immunoglobulin response to Ambrosia artemisiifolia allergen components, predisposing to sensitization
Consider IgE-specific antibody testing for ragweed allergen components if available