Expressive

rs10147522 - ZBTB25

Magnitude 2.2 · 1 study on file

Reported associations

  • An atlas of genetic influences on osteoporosis in humans and mice - Unknown journal (n.d.) · Unknown authors · PubMed 30598549

    ABSTRACT: Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative ultrasound (eBMD) in 426,824 individuals, identifying 518 genome-wide significant loci (301 novel), explaining 20% of its variance. We identified 13 bone fracture loci, all associated with eBMD, in ~1.2M individuals. We then identified target genes enriched for genes known to influence bone density and strength (maximum odds-ratio=58, p=10-75) from cell-specific features, including chromatin conformation and accessible chromatin sites. We next performed rapid-throughput skeletal phenotyping of 126 knockout mice lacking target genes and found an increased abnormal skeletal phenotype frequency compared to 526

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Adequate dietary calcium intake Moderate

    Calcium is essential for bone mineralization; individuals with genetic BMD risk benefit from optimized intake

    1000-1200 mg daily from dairy, leafy greens, or fortified foods

Exercise

  • Weight-bearing and resistance exercise Moderate

    Mechanical loading stimulates bone formation; individuals with genetic predisposition to low BMD benefit from regular activity

    150 minutes moderate aerobic activity weekly plus 2 days resistance training

Screening

  • Bone mineral density screening with DEXA scan Moderate

    rs10147522 risk allele associated with lower heel BMD; DEXA identifies individuals at increased fracture risk

    Consider baseline DEXA scan; repeat every 1-2 years if abnormal

Supplements

  • Vitamin D supplementation if deficient Moderate

    Vitamin D is required for calcium absorption and bone mineralization; individuals with genetic BMD risk benefit from adequate levels

    Check 25-OH vitamin D level; supplement 1000-2000 IU daily if <30 ng/mL