Expressive

rs10145469 - LINC02304 - LINC02325

Magnitude 2.2 · 2 studies on file

Reported associations

  • Menarche-a journey into womanhood: age at menarche and health-related outcomes in East Asians. - Human reproduction (Oxford, England) (2024) · Chiou JS, Lin YJ, Chang CY, Liang WM, Liu TY, Yang JS, Chou CH, Lu HF, Chiu ML, Lin TH, Liao CC, Huang SM, Chou IC, Li TM, Huang PY, Chien TS, Chen HR, Tsai FJ · PubMed 38527428

    Are there associations of age at menarche (AAM) with health-related outcomes in East Asians? AAM is associated with osteoporosis, Type 2 diabetes (T2D), glaucoma, and uterine fibroids, as demonstrated through observational studies, polygenic risk scores, genetic correlations, and Mendelian randomization (MR), with additional findings indicating a causal effect of BMI and T2D on earlier AAM. Puberty timing is linked to adult disease risk, but research predominantly focuses on European populations, with limited studies in other groups. We performed an AAM genome-wide association study (GWAS) with 57 890 Han Taiwanese females and examined the association between AAM and 154 disease outcomes using the Taiwanese database. Additionally, we examined genetic correlations between AAM and 113 disea

  • Elucidating the genetic architecture of reproductive ageing in the Japanese population - Unknown journal (n.d.) · Unknown authors · PubMed 29773799

    ABSTRACT: Population studies elucidating the genetic architecture of reproductive ageing have been largely limited to European ancestries, restricting the generalizability of the findings and overlooking possible key genes poorly captured by common European genetic variation. Here, we report 26 loci (all P < 5 × 10-8) for reproductive ageing, i.e. puberty timing or age at menopause, in a non-European population (up to 67,029 women of Japanese ancestry). Highlighted genes for menopause include GNRH1, which supports a primary, rather than passive, role for hypothalamic-pituitary GnRH signalling in the timing of menopause. For puberty timing, we demonstrate an aetiological role for receptor-like protein tyrosine phosphatases by combining evidence across population genetics and pre-

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