rs10143866 - PTGER2 - TXNDC16
Magnitude 2.8 · 1 study on file
Reported associations
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Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries - Unknown journal (n.d.) · Unknown authors · PubMed 24556642
ABSTRACT: Dental caries continues to be the most common chronic disease in children today. Despite the substantial involvement of genetics in the process of caries development, the specific genes contributing to dental caries remain largely unknown. We performed separate genome-wide association studies of smooth and pit-and-fissure tooth surface caries experience in the primary dentitions of self-reported white children in two samples from Iowa and rural Appalachia. In total, 1006 children (ages 3-12 years) were included for smooth surface analysis, and 979 children (ages 4-14 years) for pit-and-fissure surface analysis. Associations were tested for more than 1.2 million single nucleotide polymorphisms, either genotyped or imputed. We detected genome-wide significant signals in KPNA4 (p-va
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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high-sugar and acidic drinks and foods Moderate
Genetic predisposition to caries increases risk from dietary fermentable carbohydrates and acids
Limit sugary beverages, candy, and refined grains; rinse mouth after acidic foods or drinks
Discuss with your doctor
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preventive fluoride and sealant strategies Moderate
Genetic caries susceptibility may indicate need for enhanced preventive dental interventions
Discuss fluoride gel, varnish, or sealants with dentist based on risk profile
Lifestyle
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enhanced oral hygiene practices Moderate
Genetic predisposition warrants more aggressive preventive oral care to reduce caries incidence
Brush with fluoride toothpaste twice daily; floss daily; consider antimicrobial mouthwash
Screening
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dental caries screening Moderate
rs10143866-T carrier status associated with 1.47-fold increased smooth-surface caries risk
Schedule dental examination every 6 months; consider more frequent professional cleanings