rs10143547 - IGHV3-62 - IGHVII-62-1
Magnitude 4.5 · 1 study on file
Reported associations
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A genome-wide association study for allergen component sensitizations identifies allergen component-specific and allergen protein group-specific associations - Unknown journal (n.d.) · Unknown authors · PubMed 37780799
ABSTRACT: Background Allergic diseases are some of the most common diseases worldwide. Genome-wide association studies (GWASs) have been conducted to elucidate the genetic factors of allergic diseases. However, no GWASs for allergen component sensitization have been performed. Objective We sought to detect genetic variants associated with differences in immune responsiveness against allergen components. Methods The participants of the present study were recruited from the Tokyo Children's Health, Illness, and Development study, and allergen component-specific IgE level at age 9 years was measured by means of allergen microarray immunoassays. We performed GWASs for allergen component sensitization against each allergen (single allergen component sensitization, number of allergen compone
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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High ragweed pollen exposure during peak season Moderate
Genetic predisposition increases IgE response to ragweed allergen; minimizing exposure limits sensitization symptoms for those with elevated genetic risk.
Limit outdoor activities during peak ragweed season (August-October); use HEPA air filtration indoors
Screening
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Specific IgE testing for ragweed (Ambrosia artemisiifolia) Moderate
Variant increases susceptibility to IgE antibody responses to ragweed allergen, indicating elevated genetic risk of allergen sensitization.
Specific IgE or skin prick test for Ambrosia artemisiifolia allergen components