rs10142601 - OR6S1 - Y_RNA

Magnitude 2.2 · 1 study on file

Reported associations

• A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform - Unknown journal (n.d.) · Unknown authors · PubMed 41310232

  ABSTRACT: Most studies to date of protein quantitative trait loci (pQTLs) have relied on affinity proteomics platforms, which provide only limited information about the targeted protein isoforms and may be affected by genetic variation in their epitope binding. Here we show that mass spectrometry (MS)-based proteomics can complement these studies and provide insights into the role of specific protein isoform and epitope-altering variants. Using the Seer Proteograph nanoparticle enrichment MS platform, we identified and replicated new pQTLs in a genome-wide association study of proteins in blood plasma samples from two cohorts and evaluated previously reported pQTLs from affinity proteomics platforms. We found that >30% of the evaluated pQTLs were confirmed by MS proteomics to be consistent

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