rs10141207 - RNU6-8 - KIAA1143P1
Magnitude 2.8 · 1 study on file
Reported associations
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Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks - Unknown journal (n.d.) · Unknown authors · PubMed 29273806
ABSTRACT: We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 cases, 118,538 controls) from ethnically-diverse populations. We identified five new asthma loci, uncovered two additional novel associations at two known asthma loci, established asthma associations at two loci implicated previously in comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. Enrichment of asthma risk loci in enhancer marks, especially in immune cells, suggests a major role of these loci in the regulation of immune-related mechanisms. FULL TEXT: [INTRO] Asthma is a complex disease affecting hundreds of milli
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Genetic asthma risk with healthcare provider Moderate
rs10141207 risk allele increases asthma susceptibility; appropriate for preventive planning
Discuss with provider; consider preventive strategies and monitoring schedule
Lifestyle
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Known asthma triggers and environmental irritants Moderate
Increased genetic susceptibility to asthma makes trigger avoidance more important
Minimize exposure to allergens, air pollution, secondhand smoke, and respiratory irritants
Screening
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Asthma screening and periodic monitoring Moderate
Genetic variant associated with 1.24-fold increased asthma risk in large GWAS cohort
Baseline spirometry and symptom assessment with healthcare provider