Expressive

rs10140312 - KHNYN, CBLN3

Magnitude 2.2 · 1 study on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • aerobic exercise program Moderate

    Aerobic exercise lowers resting heart rate, which is elevated due to this SNP variant

    150 minutes moderate or 75 minutes vigorous aerobic activity weekly

Lifestyle

  • stress reduction techniques Moderate

    Stress elevates resting heart rate; mindfulness and relaxation reduce HR and cardiovascular risk

    Practice daily mindfulness, meditation, or equivalent relaxation techniques

Screening

  • resting heart rate Moderate

    This SNP is associated with elevated resting heart rate, a modifiable cardiovascular risk factor

    Monitor regularly such as annually or with vital sign checks