rs10138310 - AKAP6
Magnitude 2.2 · 1 study on file
Reported associations
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Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction - Unknown journal (n.d.) · Unknown authors · PubMed 36653681
ABSTRACT: Atrial fibrillation (AF) is a common cardiac arrhythmia resulting in increased risk of stroke. Despite highly heritable etiology, our understanding of the genetic architecture of AF remains incomplete. Here we performed a genome-wide association study in the Japanese population comprising 9,826 cases among 150,272 individuals and identified East Asian-specific rare variants associated with AF. A cross-ancestry meta-analysis of >1 million individuals, including 77,690 cases, identified 35 new susceptibility loci. Transcriptome-wide association analysis identified IL6R as a putative causal gene, suggesting the involvement of immune responses. Integrative analysis with ChIP-seq data and functional assessment using human induced pluripotent stem cell-derived cardiomyocytes demonstrat
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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regular cardiovascular exercise Low
aerobic exercise reduces atrial fibrillation risk via improved cardiac function
aim for 150 minutes moderate-intensity aerobic exercise weekly
Lifestyle
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excessive alcohol consumption Low
alcohol acutely triggers atrial fibrillation events
limit to moderate consumption or consider elimination
Screening
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atrial fibrillation baseline ECG screening Moderate
AKAP6 variant associated with increased atrial fibrillation risk
discuss baseline cardiac assessment with healthcare provider