rs10128951 - SCARB1
Magnitude 2.2 · 1 study on file
Reported associations
-
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease - Unknown journal (n.d.) · Unknown authors · PubMed 29212778
ABSTRACT: Supplemental Digital Content is available in the text. Rationale: Coronary artery disease (CAD) is a complex phenotype driven by genetic and environmental factors. Ninety-seven genetic risk loci have been identified to date, but the identification of additional susceptibility loci might be important to enhance our understanding of the genetic architecture of CAD. Objective: To expand the number of genome-wide significant loci, catalog functional insights, and enhance our understanding of the genetic architecture of CAD. Methods and Results: We performed a genome-wide association study in 34 541 CAD cases and 261 984 controls of UK Biobank resource followed by replication in 88 192 cases and 162 544 controls from CARDIoGRAMplusC4D. We identified 75 loci that replicated and
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
-
lipid panel including HDL and LDL Moderate
SCARB1 is a critical HDL receptor; risk variant may impair reverse cholesterol transport
baseline at age 20-25; repeat annually or per clinical guidelines
Lifestyle
-
aerobic exercise for cardiovascular health Moderate
exercise improves HDL levels and may offset genetic risk for atherosclerosis
150 minutes moderate intensity weekly, or 75 minutes vigorous intensity weekly
Screening
-
cardiovascular risk assessment starting at age 30 Moderate
rs10128951 affects SCARB1 expression and HDL metabolism; associated with increased coronary artery disease risk
baseline at age 30 or 5 years before earliest family CAD history; repeat every 3-5 years