rs1012564 - MIR548A1HG - RPL21P61
Magnitude 2.8 · 1 study on file
Reported associations
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A year of COVID-19 GWAS results from the GRASP portal reveals potential genetic risk factors - Unknown journal (n.d.) · Unknown authors · PubMed 35224516
ABSTRACT: Host genetic variants influence the susceptibility and severity of several infectious diseases, and the discovery of genetic associations with coronavirus disease 2019 (COVID-19) phenotypes could help to develop new therapeutic strategies to decrease its burden. Between May 2020 and June 2021, we used COVID-19 data released periodically by UK Biobank and performed 65 genome-wide association studies in up to 18 releases of COVID-19 susceptibility (n = 18,481 cases in June 2021), hospitalization (n = 3,260), severe outcomes (n = 1,244), and deaths (n = 1,104), stratified by sex and ancestry. In coherence with previous studies, we observed two independent signals at the chr3p21.31 locus (rs73062389-A, odds ratio [OR], 1.21 (P = 4.26 × 10−15) and rs71325088-C, OR, 1.62 [P = 2.25
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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COVID-19 infection risk monitoring Moderate
Genetic variant rs1012564 is associated with 1.4-fold increased risk of severe COVID-19 requiring hospitalization, suggesting heightened disease susceptibility.
Discuss COVID-19 prevention and early treatment with healthcare provider; monitor for infection symptoms.