rs10121366 - DELEC1 - U2

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association meta-analysis of cocaine dependence: Shared genetics with comorbid conditions. - Progress in neuro-psychopharmacology & biological psychiatry (2020) · Cabana-Domínguez J, Shivalikanjli A, Fernàndez-Castillo N, Cormand B · PubMed 31212010

  Cocaine dependence is a complex psychiatric disorder that is highly comorbid with other psychiatric traits. Twin and adoption studies suggest that genetic variants contribute substantially to cocaine dependence susceptibility, which has an estimated heritability of 65-79%. Here we performed a meta-analysis of genome-wide association studies of cocaine dependence using four datasets from the dbGaP repository (2085 cases and 4293 controls, all of them selected by their European ancestry). Although no genome-wide significant hits were found in the SNP-based analysis, the gene-based analysis identified HIST1H2BD as associated with cocaine-dependence (10% FDR). This gene is located in a region on chromosome 6 enriched in histone-related genes, previously associated with schizophrenia (SCZ). Fur

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