rs10120318 - LINC03131 - JKAMPP1

Magnitude 2.2 · 1 study on file

Reported associations

• Sex-specific genetic and transcriptomic liability to neuroticism - Unknown journal (n.d.) · Unknown authors · PubMed 36244801

  ABSTRACT: Background: The presentation, etiology, and relative risk of psychiatric disorders are strongly influenced by biological sex. Neuroticism is a transdiagnostic feature of psychiatric disorders displaying prominent sex differences. We performed genome-wide association studies (GWAS) of neuroticism separately in males and females to identify sex-specific genetic and transcriptomic profiles. Methods: Neuroticism scores were derived from the Eysenck Personality Inventory Neuroticism scale. GWAS were performed in 145,669 females and 129,229 males from the UK Biobank considering autosomal and X-chromosomal variation. Two-sided Z-tests were used to test for sex-specific effects of discovered loci, genetic correlates (N=673 traits), tissue and gene transcriptomic profiles, and polygenic a

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