rs10114408 - MIR4291 - BARX1 x SCG5 - GREM1

Magnitude 2.8 · 1 study on file

Reported associations

• Genome-Wide Search for Gene-Gene Interactions in Colorectal Cancer - Unknown journal (n.d.) · Unknown authors · PubMed 23300701

  ABSTRACT: Genome-wide association studies (GWAS) have successfully identified a number of single-nucleotide polymorphisms (SNPs) associated with colorectal cancer (CRC) risk. However, these susceptibility loci known today explain only a small fraction of the genetic risk. Gene-gene interaction (GxG) is considered to be one source of the missing heritability. To address this, we performed a genome-wide search for pair-wise GxG associated with CRC risk using 8,380 cases and 10,558 controls in the discovery phase and 2,527 cases and 2,658 controls in the replication phase. We developed a simple, but powerful method for testing interaction, which we term the Average Risk Due to Interaction (ARDI). With this method, we conducted a genome-wide search to identify SNPs showing evidence for GxG wit

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