rs1011121 - RNU6-758P - CFDP1

Magnitude 2.2 · 1 study on file

Reported associations

• A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N = 223,773) - Unknown journal (n.d.) · Unknown authors · PubMed 29397368

  ABSTRACT: Background Headache is the most common neurological symptom and a leading cause of years lived with disability. We sought to identify the genetic variants associated with a broadly-defined headache phenotype in 223,773 subjects from the UK Biobank cohort. Methods We defined headache based on a specific question answered by the UK Biobank participants. We performed a genome-wide association study of headache as a single entity, using 74,461 cases and 149,312 controls. Results We identified 3343 SNPs which reached the genome-wide significance level of P < 5 × 10− 8. The SNPs were located in 28 loci, with the top SNP of rs11172113 in the LRP1 gene having a P value of 4.92 × 10− 47. Of the 28 loci, 14 have previously been associated with migraine. Among 14 new loci, rs7

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