rs10110943 - PSD3

Magnitude 2.2 · 1 study on file

Reported associations

• Genome wide association study identifies two loci associated with cadmium in erythrocytes among never-smokers. - Human molecular genetics (2017) · Borné Y, Söderholm M, Barregard L, Fagerberg B, Persson M, Melander O, Thévenod F, Hedblad B, Engström G · PubMed 27005419

  Cadmium is a non-essential toxic metal with multiple adverse health effects. Exposure in the general population occurs by smoking and diet. Cadmium in erythrocytes is a valid biomarker of exposure and body burden of cadmium. We aimed to identify genetic variants related to concentrations of cadmium in erythrocytes. Erythrocyte cadmium was analyzed in 4432 individuals (1728 never smokers) from the Swedish population-based Malmö Diet and Cancer cohort. Genotyping was performed using the Illumina HumanOmniExpressExome Bead chip with genome-wide coverage. Genome wide analyses were performed in the whole sample and in never smokers. No single nucleotide polymorphism (SNP) reached a genome-wide significant association with erythrocyte cadmium in the whole sample. However, in never smokers, 14 v

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