rs10109703 - LINC02950 - RN7SL178P

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes - Unknown journal (n.d.) · Unknown authors · PubMed 33987465

  ABSTRACT: Objective To discover genetic determinants of Parkinson disease (PD) motor subtypes, including tremor dominant (TD) and postural instability/gait difficulty (PIGD) forms. Methods In 3,212 PD cases of European ancestry, we performed a genome-wide association study (GWAS) examining 2 complementary outcome traits derived from the Unified Parkinson's Disease Rating Scale, including dichotomous motor subtype (TD vs PIGD) or a continuous tremor/PIGD score ratio. Logistic or linear regression models were adjusted for sex, age at onset, disease duration, and 5 ancestry principal components, followed by meta-analysis. Results Among 71 established PD risk variants, we detected multiple suggestive associations with PD motor subtype, including GPNMB (rs199351, psubtype = 0.01, pratio = 0.03)

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