rs10108262 - EIF3H

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study of colorectal polyps identified highly overlapping polygenic architecture with colorectal cancer. - Journal of human genetics (2022) · Hikino K, Koido M, Otomo N, Tomizuka K, Ikegawa S, Matsuda K, Momozawa Y, Mushiroda T, Terao C · PubMed 34671089

  No genome-wide association studies (GWAS) were reported for colorectal polyps and the overlap in polygenic backgrounds conferring risk of colorectal cancer and polyps remains unclear. We performed GWAS on subjects with colorectal polyps using the BioBank Japan data with 4447 cases and 157,226 controls. We evaluated genetic correlations between colorectal polyps and cancer, and effects on colorectal polyps of single nucleotide polymorphisms (SNPs) known to be associated with colorectal cancer. We identified CUX2, a known genetic locus to colorectal cancer, as a susceptibility locus to colorectal polyps (p value = 1.1 × 10 ). Subsequent fine-mapping analysis indicated that rs11065828 in CUX2 is the causal variant for colorectal polyps. We found that known colorectal cancer-susceptib

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