rs1010810 - LINC01900, GATA6-AS1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Unknown journal (n.d.) · Unknown authors · PubMed 40436827
ABSTRACT: Genome-wide association studies (GWAS) have predominantly focused on European ancestry populations, limiting biological discoveries across diverse populations. Here we report GWAS findings from 153,950 individuals across 36 quantitative traits in the Korean Cancer Prevention Study-II (KCPS2) Biobank. We discovered 301 previously unreported genetic loci in KCPS2, including an association between thyroid-stimulating hormone and CD36. Meta-analysis with the Korean Genome and Epidemiology Study, Biobank Japan, Taiwan Biobank, and UK Biobank identified 4588 loci that were not significant in any contributing GWAS. We describe differences in genetic architectures across these East Asian and European samples. We also highlight East Asian specific associations, including a known pleiotrop
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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lipid panel screening Moderate
rs1010810-A allele associates with elevated LDL and total cholesterol in genome-wide study of 928,679 individuals
Annual lipid panel screening; escalate frequency if elevated results
Diet
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heart-healthy diet for cholesterol management Moderate
Dietary reduction of saturated fat can mitigate genetic predisposition to elevated cholesterol and LDL
Consider Mediterranean or DASH diet; limit saturated fat intake
Discuss with your doctor
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genetic cholesterol predisposition and cardiovascular risk management Moderate
Genetic contribution to cholesterol warrants individualized assessment of cardiovascular risk and treatment thresholds