rs10107882 - SBSPON

Magnitude 2.0 · 1 study on file

Reported associations

• The genetic architecture of the corpus callosum and its genetic overlap with common neuropsychiatric diseases. - Journal of affective disorders (2023) · Chen SJ, Wu BS, Ge YJ, Chen SD, Ou YN, Dong Q, Feng J, Cheng W, Yu JT · PubMed 37164063

  The corpus callosum (CC) is the main structure transferring information between the cerebral hemispheres. Although previous large-scale genome-wide association study (GWAS) has illustrated the genetic architecture of white matter integrity of CC, CC volume is less stressed. Using MRI data from 33,861 individuals in UK Biobank, we conducted univariate and multivariate GWAS for CC fractional anisotropy (FA) and volume with PLINK 2.0 and MOSTest. All discovered SNPs in the multivariate framework were functionally annotated in FUMA v1.3.8. In the meanwhile, a series of gene property analyses was conducted simultaneously. In addition, we estimated genetic relationship between CC metrics and other neuropsychiatric traits and diseases. We identified a total of 36 and 82 significant genomic loci f

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