Expressive

rs10106829 - PPP1R3B-DT

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genetic architecture and risk prediction of gestational diabetes mellitus in Chinese pregnancies - Unknown journal (n.d.) · Unknown authors · PubMed 40325049

    ABSTRACT: Gestational diabetes mellitus, a heritable metabolic disorder and the most common pregnancy-related condition, remains understudied regarding its genetic architecture and its potential for early prediction using genetic data. Here we conducted genome-wide association studies on 116,144 Chinese pregnancies, leveraging their non-invasive prenatal test sequencing data and detailed prenatal records. We identified 13 novel loci for gestational diabetes mellitus and 111 for five glycemic traits, with minor allele frequencies of 0.01-0.5 and absolute effect sizes of 0.03-0.62. Approximately 50% of these loci were specific to gestational diabetes mellitus and gestational glycemic levels, distinct from type 2 diabetes and general glycemic levels in East Asians. A machine learning model in

  • The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians - Unknown journal (n.d.) · Unknown authors · PubMed 36333282

    ABSTRACT: Metabolic traits are heritable phenotypes widely-used in assessing the risk of various diseases. We conduct a genome-wide association analysis (GWAS) of nine metabolic traits (including glycemic, lipid, liver enzyme levels) in 125,872 Korean subjects genotyped with the Korea Biobank Array. Following meta-analysis with GWAS from Biobank Japan identify 144 novel signals (MAF ≥ 1%), of which 57.0% are replicated in UK Biobank. Additionally, we discover 66 rare (MAF < 1%) variants, 94.4% of them co-incident to common loci, adding to allelic series. Although rare variants have limited contribution to overall trait variance, these lead, in carriers, substantial loss of predictive accuracy from polygenic predictions of disease risk from common variant alone. We capture groups

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • HDL cholesterol level Moderate

    rs10106829 associated with reduced HDL cholesterol, an independent cardiovascular risk factor

    Annual lipid panel; target HDL >40 mg/dL (men) or >50 mg/dL (women)

Diet

  • Emphasize whole grains, reduce refined carbohydrates Moderate

    Low glycemic load diet improves glucose tolerance and insulin sensitivity to counter genetic predisposition

    Replace refined grains with whole grains; limit added sugars

Exercise

  • Regular aerobic and resistance exercise Moderate

    Physical activity enhances insulin sensitivity and glucose tolerance, mitigating genetic hyperglycemia risk

    150 minutes moderate aerobic activity and 2 resistance sessions weekly

Screening

  • Fasting glucose and glucose tolerance testing High

    rs10106829 is strongly associated with elevated fasting glucose and impaired glucose tolerance

    Annual fasting glucose test; oral glucose tolerance test if baseline elevated