Expressive

rs10106488 - EBF2

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Hernia prevention and early intervention strategies Moderate

    Genetic predisposition warrants individualized risk reduction strategy and discussion of surgical options if hernia develops.

Lifestyle

  • Heavy lifting and straining Moderate

    Heavy lifting and straining increase abdominal pressure, which is a known mechanical precipitant for hernia in genetically susceptible individuals.

    Avoid lifting >25 kg, use proper lifting technique, manage constipation

  • Weight management for hernia risk reduction Moderate

    Obesity increases intra-abdominal pressure and hernia risk; weight management reduces mechanical stress on the abdominal wall.

    Maintain BMI in normal range (less than 25 kg/m2)

Screening

  • Inguinal hernia symptoms Moderate

    Genetic variant significantly increases hernia susceptibility (OR 1.14); early detection enables timely intervention.

    Annual self-examination and physician screening