rs10102859 - ADAM7-AS1
Magnitude 2.2 · 1 study on file
Reported associations
-
Genome‐wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway - Unknown journal (n.d.) · Unknown authors · PubMed 29532581
ABSTRACT: Abstract The heritability of nicotine dependence based on family studies is substantial. Nevertheless, knowledge of the underlying genetic architecture remains meager. Our aim was to identify novel genetic variants responsible for interindividual differences in smoking behavior. We performed a genome‐wide association study on 1715 ever smokers ascertained from the population‐based Finnish Twin Cohort enriched for heavy smoking. Data imputation used the 1000 Genomes Phase I reference panel together with a whole genome sequence‐based Finnish reference panel. We analyzed three measures of nicotine addiction-smoking quantity, nicotine dependence and nicotine withdrawal. We annotated all genome‐wide significant SNPs for their functional potential. First, we detected genome
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
Pharmacological smoking cessation support Moderate
This variant is associated with more severe nicotine withdrawal symptoms, suggesting potential benefit from pharmacotherapy during cessation attempts.
Discuss nicotine replacement, bupropion, or varenicline with your doctor if attempting smoking cessation.