rs1010235 - DAB2IP

Magnitude 2.2 · 1 study on file

Reported associations

• "The Heidelberg Five" personality dimensions: Genome-wide associations, polygenic risk for neuroticism, and psychopathology 20 years after assessment. - American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (2021) · Heilbronner U, Papiol S, Budde M, Andlauer TFM, Strohmaier J, Streit F, Frank J, Degenhardt F, Heilmann-Heimbach S, Witt SH, Forstner AJ, Loerbroks A, Amelang M, Stürmer T, Müller-Myhsok B, Nöthen MM, Rietschel M, Schulze TG · PubMed 33590662

  HeiDE is a longitudinal population-based study that started in the 1990s and, at baseline, assessed an array of health-related personality questionnaires in 5133 individuals. Five latent personality dimensions (The Heidelberg Five) were identified and interpreted as Emotional Lability (ELAB), Lack of Behavioral Control (LBCN), Type A Behavior (TYAB), Locus of Control over Disease (LOCC), and Psychoticism (PSYC). At follow-up, 3268 HeiDE participants (post-QC) were genotyped on single nucleotide polymorphism (SNP) arrays. To further characterize The Heidelberg Five, we analyzed genomic underpinnings, their relations to the genetic basis of the Big Five trait Neuroticism, and longitudinal associations with psychiatric symptoms at follow-up. SNP-based heritability was significant for ELAB (34

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